The occurrence of permafrost thawing settlement would lead to soil sliding to its base along slope when the pipeline was in slope segment, which lead to form a thawing landslide, and the stress distribution of the buried pipelines located in permafrost zone ramping portion had greatly affected, and might lead to pipeline stress concentration even plastic deformation phenomenon. For buried pipelines in the slopes with different angles and the length of permafrost thawing settlement, stress changes of pipeline numerically when affected by thawing landslide and thawing settlement were simulated. The study found that different positions pipeline showed different forms of stress when it was affected by thawing landslide, and stress magnitude generated by the pipeline at different locations affected slope angles. The results provided a better theoretical basis for the safe operation and construction of the building buried pipelines.